Principal Investigator

Ongoing Projects

1. DBT - To Investigate the Role of Human Mesenchymal Stem Cell-Derived Exosomes as a Cell-Free Therapeutic Approach for the amelioration of Symptoms of Autism Spectrum Disorders.

2. DBT - Development of Amniotic Membrane and Nano-Fiber Composite Scaffold for Tissue Regeneration.

3. ICMR - Functionalized 3D Printed Tracheal Analogue for multivariate Translational Application

4. DHR - Novel bioink-based 3D printed organoid as a high-throughput platform for animal-free drug screening in cardiac spectrum of disease

5. SERB - Enhancing the translational potential of human mesenchymal stem cell-derived extracellular vesicles via multivariate bioengineering strategies

Completed Projects

1. ICMR - Development of bioactive and personalized three dimensional bioprinted tissue implant for burn, trauma and plastic surgery patients

2. Ramalingas - Epigenetic fibrosis modulation for corneal scars:combined therapy with DNMT inhibitors and corneal stromal stem cell derived extracellular vesicle.

3. ICMR - Investigating mesenchymal stem cell derived extracellular vesicles as cell free therapeutic approach in Asherman syndrome

Co- Principal Investigator

Ongoing Project:

1. ICMR - Role of Autologous Stem Cell and Platelet Rich Plasma Therapy Regenerating Endometrium in Women with Asherman Syndrome and atrophic Endometrium-A pilot study.

2. ICMR - Differentiation, Molecular Characterization & Translational application of culture-expanded human corneal Endothelial cells

3. DBT Biocare - Biofabrication of human amniotic membrane- based functional bone implant scaffold for augmented osteogenesis

4. ICMR - Assessing the efficacy of Engineered Extracellular vesicles targeting NLRP3 inflammasomes in Neuroinflammatory disease model

5. AIIMS - Translational potential of mesenchymal stem cells in generation of immunotolerance during solid organ transplantation

6. DST SERB - Human induced pluripotent stem cell-based functional characterization of novel identified disease causal variants in families with juvenile Parkinson’s disease

7. AIIMS Intramural - A Pilot prospective Randomized controlled trials to compare recovery following hip fracture arthroplasty using allogenic Wharton jelly derived stem cell verses platelet rich plasma double- blinded study.

8. TATA - Functional characterisation of patient derived single cell speroids from Oral squamous cell carcinoma to decipher clinical hererogeneity: A tool for drug screening and radiation sensitivity

9. ICMR - Validating biomarker panel in five different cohorts to define and predict biological ageing, diseaseburden and mortality in human subjects- a pilot prospective cohort study

10. UCL AIIMS 18 - Skeletal muscle regeneration following total knee arthroplasty: limitation of the intrisic stem cell pool

11. ICMR - Phase 1 clinical trail to explore the feasibility and evaluate the clinical outcomes and safety of keratoplasty using bioenginnereddecallized cross linked human cornea graft in comparision with fresh human cornea. A novaltherapeuitic approach to combat.

12. ICMR - Development of easy to use fibrin based rapidly acting bleeding control biopolymer sheet

13. ICMR - Generation, characterization and differentiation of induced pluripotent stem

14. cells (iPSCs) into motor neurons from spinal muscular atrophy prenatal

15. samples- Recapitulating the disease in the dish.

16. DBT - Deciphering the role of microRNA-191, in ragulation of chemoresistance and stemness in breast cancer

17. DST SERB - Assessment of Epigenetic modulation by microvesicle mediated mitochonriraltransplkantation in diabetes as a novel therapeutic approach

18. SERB - Immunomodulatory property of preconditioned human mesenchymal stem

19. cell-derived conditioned media: Assessment of its therapeutic potential in

20. systemic lupus erythematosus

Completed Projects

1. ICMR - Fabrication and characterization of hydrogel sheet with mesenchymal stem cells and extracellular vesicle to study its therapeutic efficacy and saftey in wound healing of patients with inherited epidermolysisbullosa

2. ICMR - Al-enabled multi- channel optical coherence imaging (OCI-mX): A label-free imaging plateform for high throughput anti-cancer drug screening in 3D tumor spheroids

3. ICMR - An alternative model to study nervous system dysfunction in Alzheimer disease using patient specific iPSC- derived 3D brain organoids

4. SIBRI - Biomimetic chemo-attenuated plasmodium vaccine

5. DBT - Label-free high-throughput volumetric interferometric microscopy for rapid drug screening in 3D tumor microenvironment

6. Intra disciplinary Intramural Research Project - Gneration of 3D Breast Tumor organoids as an In vitro drug screening study model

7. Intramural AIIMS - Comparing outcomes post autologous stem cell transplantation with hematopoietic stem cell stored at 2-8º C verses cryopreserved hematopoietic stem cells